临床指南强力推荐羧肽酶应用于高剂量甲氨蝶呤的解毒药物
高剂量甲氨蝶呤引起的急性肾损伤是一种严重的致命性毒性。羧肽酶是一种经FDA批准的用于治疗高剂量甲氨蝶呤导致肾功能障碍的药物。本文主要针对应用羧肽酶治疗高剂量甲氨蝶呤引起急性肾损伤以及甲氨蝶呤清除延迟患者的相关内容提出指导意见，内容涉及用药人群识别以及药物用法等。
该指南最终达成共识，当高剂量甲氨蝶呤使用时，强力推荐使用羧肽酶，并且该指南的落实有助于降低高剂量甲氨蝶呤带来的生命威胁。
该临床指南的制定团队由资深的临床工作者制定，包括肿瘤科医师，肾科医师，药剂师，临床药理学家和护士等，并且得到国家癌症研究所（NCI）的支持。
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